First head-to-head trial pits psychedelic therapy against antidepressant

For the first time, a trial has directly compared the efficacy of psychedelic psilocybin psychotherapy for depression against a common antidepressant medication

A first-of-its-kind clinical trial has pitted a common antidepressant against psilocybin, the main psychedelic compound found in magic mushrooms. The results, recently published in the New England Journal of Medicine, are decidedly mixed with the primary depression measure revealing no significant difference between the two treatments, but a number of secondary measures notably favoring psilocybin.

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